The role of nucleosomes and H3.1

Nucleosomes are small fragments of chromosomes released into the blood during cell death and consist of a histone octamer core with DNA wrapped around it. Histone proteins could be modified by a variety of post-translational modifications (PTMs) also called epigenetic modifications, such as methylation, acetylation, phosphorylation or citrullination. In epigenetics, modifications to histones, including H3, play a key role in regulating gene expression.

Measuring and monitoring

Measuring and monitoring nucleosome levels and modifications in circulating blood has the potential to aid diagnosis, prognosis and monitoring of many human diseases.

Nu.Q^® Discover is built on Volition’s cutting-edge nucleosome quantification technology and adds value across the drug development pipeline, with applications in:

• Oncology
• Neurodegenerative diseases
• Autoimmune diseases
• NETosis

Our biomarkers

Our biomarkers support the entire drug discovery and development process from pre-clinical testing to market-ready. We aim to assess disease severity, monitor treatment response, and enhance the understanding of disease pathology and treatments.