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Looking for an alternative to the discontinued Roche Cell Death ELISA kit?

Volition Nu.Q® H3.1 Kit

Nu.Q® Discover H3.1 Kit

Nu.Q® H3.1 ELISA

Nu.Q® Discover H3.1 Assay

Looking for an Alternative to the Roche Cell Death Detection ELISA?

The Roche Cell Death Detection ELISA and Cell Death Detection ELISAPLUS kits have been widely used for the quantitative measurement of histone-associated DNA fragments released during apoptosis. These assays enabled researchers to detect mono- and oligonucleosomes generated during programmed cell death and have become a standard tool in apoptosis research for many laboratories worldwide.

With the Roche assay now discontinued, researchers are seeking a reliable alternative for studying nucleosome release, chromatin fragmentation, cell death pathways, and inflammatory responses.

The Nu.Q® Discover H3.1 ELISA offers a robust approach for measuring nucleosome-associated histones and monitoring chromatin release across a range of cell death and inflammation studies.

Whether you are replacing an existing apoptosis workflow or developing new cell death assays, Nu.Q® Discover provides a simple ELISA-based solution backed by Volition’s expertise in nucleosome biology.

Related Resource

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Cell Death White Paper, Nu.Q® Discover

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Comparison

Roche Cell Death Detection ELISA Alternative

How does Nu.Q® Discover H3.1 compare?

Looking for a Roche Cell Death Detection ELISA alternative?
Nu.Q® Discover H3.1 offers a standardised, analytically validated RUO ELISA for measuring circulating intact nucleosomes containing histone H3.1 in EDTA plasma, with quantitative results in ng/ml.

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About H3.1

About H3.1 nucleosome research use only assay

Our Nu.Q® Discover H3.1 Research Use Only Assay detects quantitative levels of circulating intact nucleosomes containing histone H3.1 in plasma.

It is an analytically validated quantitative assay and calibrated in ng/ml using recombinant nucleosomes. Unlike other kits, Volition’s H3.1 is an ‘all-in-one’ kit, including a standard curve. Our test was developed based on CLSI guidelines and is validated for use in EDTA plasma, making it standardized and ideal for measuring apoptosis, NETosis, or histone complexes.

Nu.Q® Discover H3.1 Research Use Only Assay can be run manually on an ELISA sandwich immunoassay or an automated platform.

If you are measuring cell death detection or examining circulating cell-free nucleosomes that contain histone H3.1 as part of your research – for profiling post-translational modifications, histone variants, or DNA modifications – Nu.Q® Discover H3.1 Research Use Only Assay can be a powerful addition to your epigenetic toolbox.

Volition Nu.Q® Discover H3.1 Research Use Only KitNu.Q® Discover H3.1 RUO Kit - Product information
FAQs

Frequently Asked Questions

  • The Roche Cell Death Detection ELISA kit has been discontinued and may no longer be available through suppliers.

  • Researchers studying nucleosome release can consider assays that detect nucleosome-associated histones, such as the Nu.Q® Discover H3.1 ELISA.

  • Yes. During apoptosis, chromatin fragmentation leads to the release of nucleosomes, which can be detected using ELISA-based assays.

testimonial
The kit has been crucial in our research. Its ability to handle small sample volumes while delivering rapid and sensitive results has broadened our biomarker research capabilities, specifically after the comparison with other similar products from different companies. The kit's accuracy and reliability have significantly contributed to our preclinical translational study and proceed it to clinical phase II studies.
Fuhong Su MD, PhD
COO of Labo Unité de Soins Intensifs, Hôpital Erasme, Université Libre de Bruxelles
Product Resources

Brochure & Clinical Papers

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Cell Death White Paper, Nu.Q® Discover

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